Isotopically Labeled Compounds
Medchemexpress LLC Pentan-3-amine-d5 | 1219802-43-3 | 92.19 g/mol | C5H8D5N | 5 MG
Pentan-3-amine-d5 is the deuterium-labeled isotopologue of pentan-3-amine used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, and LC-MS. It is supplied as a liquid that is colorless to light yellow and is intended for analytical applications requiring isotopically labeled standards.
- Deuterium-labeled pentan-3-amine for tracer and internal standard use.
- Suitable for NMR, GC-MS, and LC-MS quantitative analysis.
- Molecular formula C5H8D5N and molecular weight 92.19 g/mol.
- Physical form: liquid, colorless to light yellow.
- Storage guidance includes -20°C for long-term stability; in solvent, store at -80°C for extended periods.
- Available in a small research-scale quantity (5 mg).
Medchemexpress LLC HY-15777AS 5mg , Ribociclib-d6 (hydrochloride) CAS: Purity:>98%
HY-15777AS 5mg Ribociclib-d6 (hydrochloride) CAS: Ribociclib D6 (LEE011 D6) hydrochloride is a deuterium labeled Ribociclib. Ribociclib is a highly specific CDK4/6 inhibitor with IC50 values of 10 nM and 39 nM, respectively, and is over 1,000-fold less potent against the cyclin B/CDK1 complex. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.
Medchemexpress LLC Prazosin-d8 | 1006717-55-0 | 98.0% | 5 MG
Prazosin-d8 is a deuterium labeled form of Prazosin. Prazosin is an alpha-adrenergic blocker and sympatholytic drug. It is used to treat conditions such as high blood pressure, anxiety, PTSD, and panic disorder.
- Deuterium labeled compound
- Alpha-adrenergic blocker
- Sympatholytic drug
- Used in high blood pressure treatment
- Applied in managing anxiety and PTSD
- Effective in treating panic disorder
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
- Deuteration can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC D-Glucose-d12-1 | 89798-27-6 | 99.4% | 5 MG
D-Glucose-d12-1 is the deuterium labeled D-Glucose. D-Glucose (Glucose), a monosaccharide, is an important carbohydrate in biology. It is a carbohydrate sweetener and a critical component of general metabolism, serving as a critical signaling molecule in relation to both cellular metabolic status and biotic and abiotic stress response.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process.
- Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC o-Toluic acid-13C | 70838-82-3 | 99% | 137.14 | 5 MG
o-Toluic acid-13C is the 13C labeled o-Toluic acid. It is a benzoic acid substituted by a methyl group at position 2, playing a role as a xenobiotic metabolite. This compound is intended for research use only and is not for sale to patients.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Incorporates stable heavy isotopes of hydrogen, carbon, and other elements into drug molecules as tracers for quantitation during the drug development process.
- Potential to affect the pharmacokinetic and metabolic profiles of drugs.
Medchemexpress LLC 7-keto-Deoxycholic acid | 911-40-0 | 99.7% | 406.56 | 50 MG
7-keto-Deoxycholic acid is a metabolite of bile acids found in *Clostridium absonum* and is also converted by *Lactobacillus* and *Bifidobacterium* under specific conditions. In vitro research shows that it exhibits an increased bioconversion rate with the addition of an equimolar concentration of deoxycholic acid, suggesting it is induced and subsequently metabolized. For example, *E. lentum*-like c-25 has been shown to convert cholic acid to deoxycholic acid and 7-keto-Deoxycholic acid during anaerobic incubation.
- Metabolite of bile acids in *Clostridium absonum*
- Converted by *Lactobacillus* and *Bifidobacterium*
- Bioconversion rate increases with deoxycholic acid
- Soluble in DMSO at 100 mg/mL
- Store at 4°C, protected from light
- In solvent, store at -80°C for 6 months or -20°C for 1 month
Medchemexpress LLC Octopamine-d4 hydrochloride | 1219803-62-9 | 98.3% | 5 MG
Octopamine-d4 (hydrochloride) is the deuterium labeled Octopamine hydrochloride. Octopamine ((±)-p-Octopamine) hydrochloride, a biogenic monoamine structurally related to noradrenaline, acts as a neurohormone, a neuromodulator and a neurotransmitter in invertebrates. Octopamine hydrochloride can stimulate alpha2-adrenoceptors (ARs) in Chinese hamster ovary cells transfected with human alpha2-ARs. It has been shown to increase glycogenolysis, glycolysis, oxygen uptake, gluconeogenesis and the portal perfusion pressure.
- Molecular formula: C8H9D3CINO2
- Molecular weight: 192.66
- Target: Adrenergic receptor; endogenous metabolite
- Pathway: GPCR/G protein; neuronal signaling; metabolic enzyme/protease
- Storage: 4°C, sealed storage, away from moisture. In solvent: -80°C for 6 months; -20°C for 1 month (sealed storage, away from moisture).
- Solubility (in vitro): DMSO: ≥ 100 mg/mL (519.05 mM); H2O: ≥ 50 mg/mL (259.52 mM)
Medchemexpress LLC Maprotiline-d3 hydrochloride | 1329496-63-0 | 98.8% | 5 MG
Maprotiline-d3 (hydrochloride) is a deuterium labeled version of Maprotiline (hydrochloride) and is intended for research use only.
- Can be utilized as a tracer.
- Functions as an internal standard for quantitative analysis using techniques such as NMR, GC-MS, or LC-MS.
- Deuterium substitution can influence the pharmacokinetic and metabolic profiles of drugs.
Cambridge Isotope Laboratories Sodium L-Lactate (13C3, 98%) 20% W/W In H2O, 0.5g
Sodium L-Lactate (13C3, 98%) 20% W/W In H2O, 201595-71-3, CH3*CH(OH)*COONa, 115.04, 0.5g
Cayman Chemical RIvaroxabn-d4 500ug
An internal standard for the quantification of rivaroxaban by GC- or LC-MS
Medchemexpress LLC Triamterene-d5 | 1189922-23-3 | 99.8% | 5 MG
Triamterene-d5 is a deuterium labeled variant of Triamterene. It functions as a mild diuretic by blocking the epithelial Na+ channel (ENaC) in a voltage-dependent manner and is also an inhibitor of the TGR5 receptor. This compound can be used as a tracer or an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
- Blocks epithelial Na+ channel (ENaC) in a voltage-dependent manner
- Functions as a mild diuretic
- Inhibitor of the TGR5 receptor
- Can be used as a tracer
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS
Medchemexpress LLC Acipimox-d4 | 1246816-28-3 | 1 MG
Acipimox-d4 is a deuterium-labeled version of Acipimox (K-9321), which is a nicotinic acid analogue known for its antilipolytic properties. This compound effectively inhibits lipolysis and reduces systemic levels of free fatty acids (FFAs), thereby improving insulin sensitivity. It is intended for research use only and not for patient administration.
- Deuterium labeled compound
- Nicotinic acid analogue
- Exhibits antilipolytic activity
- Suppresses systemic free fatty acids
- Improves insulin sensitivity
- Suitable as a tracer in research
- Can serve as an internal standard for quantitative analysis (e.g., NMR, GC-MS, LC-MS)
- Incorporation of stable heavy isotopes can affect pharmacokinetic and metabolic profiles of drugs
Medchemexpress LLC Dopamine-13C,15N hydrochloride | 369656-74-6 | 99.0% | 5 MG
Dopamine-13C,15N (hydrochloride) is the 13C and 15N labeled Dopamine hydrochloride. It is intended for research use only and not for sale to patients. This compound can be used as a tracer and as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS. Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, primarily as tracers for quantitation during the drug development process. Deuteration has also garnered attention due to its potential impact on the pharmacokinetic and metabolic profiles of drugs.
- Dopamine-13C,15N (hydrochloride) is the 13C and 15N labeled Dopamine hydrochloride.
- Can be used as a tracer.
- Can be used as an internal standard for quantitative analysis by NMR, GC-MS, or LC-MS.
Medchemexpress LLC L-tryptophan-d8 | 1233395-93-1 | 98.0% | 212.27 g/mol | C11H4D8N2O2 | 10 MG
L-Tryptophan-d8 is the deuterium-labeled form of the essential amino acid L-tryptophan, provided as a solid isotopic standard for analytical and metabolic applications. It is commonly used as an internal standard in mass spectrometry and tracer studies to distinguish labeled from endogenous tryptophan.
- Deuterium labeled (d8).
- Used as an isotopic internal standard for mass spectrometry and tracer studies.
- Purity 98.0%.
- Molecular formula C11H4D8N2O2; molecular weight 212.27 g/mol.
- Physical form solid (powder), supplied as 10 mg unit.
- Storage: 4°C for solid; in solution -80°C (up to 6 months) or -20°C (up to 1 month), sealed and protected from moisture and light.
- CAS number 1233395-93-1.
Medchemexpress LLC Mirtazapine-d3 | 1216678-68-0 | 99.7% | 1 ML
Mirtazapine-d3 is a deuterium labeled Mirtazapine, which is a potent and orally active noradrenergic and specific serotonergic antidepressant (NaSSA) agent. It functions by blocking 5-HT2 and 5-HT3 receptors, and is intended for research use only.
- Deuterium labeled Mirtazapine
- 5-HT receptor inhibitor
- Potent noradrenergic and specific serotonergic antidepressant (NaSSA) agent
- Blocks 5-HT2 and 5-HT3 receptors
- Can be used as a tracer
- Suitable as an internal standard for quantitative analysis (NMR, GC-MS, LC-MS)